Guyer is a surname. Notable people with the surname include:
Adolf Guyer-Zeller (1839–1899), Swiss entrepreneur Brandon Guyer (born 1986), American baseball player Charlie Guyer (1909–1977), Australian football player Cindy Guyer (born 1961), American model and actress Denis Guyer (born 1966), American politician Gino Guyer (born 1983), American ice hockey player Gordon Guyer (born 1926), American academic administrator from Michigan Irving Guyer (1916–2012), American painter Jane I. Guyer (born 1943), American anthropologist Josh Guyer (born 1994), Australian baseball player Léonie Guyer (born 1955), American artist Lisa Guyer (born 1963) American singer, guitarist, and songwriter Lux Guyer (1894–1955), Swiss architect Michael F. Guyer (1874–1959), American cytologist and zoologist Murphy Guyer (born 1952), American actor, playwright, writer and director Paul Guyer, American philosopher Percy Guyer, pseudonym of songwriter Septimus Winner Roy J. Guyer (1885–1956), American college athlete and coach Reyn Guyer (born 1935), American inventor of Twister Tennyson Guyer (1913–1981), American politician Thad McIntosh Guyer (born 1950), American civil rights lawyer U. S. Guyer (1868–1943), American politician from Kansas
Other uses Dowleh Guyer, a village in Iran