Holcomycteronus is a genus of cusk-eels. It includes Holcomycteronus profundissimus, long thought to be the deepest-living fish in the world's oceans.

Species There are currently six recognized species in this genus. Many were formerly considered species of Neobythites or Grimaldichthys. Holcomycteronus aequatoris (H. M. Smith & Radcliffe, 1913) Holcomycteronus brucei (Dollo, 1906) Holcomycteronus digittatus Garman, 1899 Holcomycteronus profundissimus (Roule, 1913) Holcomycteronus pterotus (Alcock, 1890) Holcomycteronus squamosus (Roule, 1916)

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