The 1946 United States Senate election in Pennsylvania was held on November 5, 1946. Incumbent Democratic U.S. Senator Joseph F. Guffey sought re-election to another term, but was defeated by Republican nominee Edward Martin. This was the last time that the Republican candidate won Philadelphia in an election for the Class 1 Senate seat.
General election Candidates Joseph F. Guffey, incumbent U.S. Senator (Democratic) Frank Knotek (Socialist Labor) Dale H. Learn, East Stroudsburg real estate agent (Prohibition) Edward Martin, Governor of Pennsylvania (Republican)
Results
|-bgcolor="#EEEEEE" | colspan="3" align="right" | Totals | align="right" | 3,127,860 | align="right" | 100.00% | align="right" |
References