Vlădescu is a Romanian surname. Notable people with the surname include:
G. M. Vlădescu (1885–1952), writer Matei Vlădescu (1835–1901), general Mihail Vlădescu (1865–1944), botanist and politician Radu G. Vlădescu (1886–1964), academic Sebastian Vlădescu (born 1958), economist and politician Gheorghe Vlădescu-Răcoasa (1895–1989), sociologist and politician