De Villegas is a surname. Notable people with the surname include:
Andrés Rodríguez de Villegas (died 1633), Spanish colonial governor Diogo Ortiz de Villegas (1457–1519), Spanish Roman Catholic priest Esteban Manuel de Villegas (1589–1669), Spanish poet Hipólito de Villegas (c. 1761 – 1838), Chilean politician Pedro Ruiz de Villegas II (c. 1304–1355), Spanish noble Pedro de Villegas Marmolejo (1519–1596), Spanish Renaissance sculptor and painter Maria de Villegas de Saint-Pierre (1870-1941), Belgian Countess, writer, nurse and philanthropist
See also Liga Georgina de Villegas, basketball league in Honduras 15785 de Villegas, main-belt minor planet Villegas (disambiguation)