Megali Panagia (, "Great Panagia") is a common name found on churches, monasteries and towns in Greece to honor the Virgin Mary.
Megali Panagia may refer to: Megali Panagia, Chalkidiki, a village in Chalkidiki peninsula and seat of old Panagia municipality Church of Megali Panagia, a church built on the site of Hadrian's Library in Athens, now in ruins