Humphrey Smith may refer to
Politicians Humphrey "Yankee" Smith (1774–1857), unofficial founder of the city of Smithville, Missouri and abolitionist Humphrey Smith (MP) (1542–1589), MP for Bodmin
Others Humphrey Smith (Quaker) (died 1663), religious writer Humphrey Smith Racing, NASCAR racing team Humphrey Smith (businessman) (1944–2026), owner of Samuel Smith Old Brewery Humphrey Smith, fictional character in The Sins of St. Anthony