Polychronis is a masculine Greek given name Πολυχρόνης. Notable people with the name include:

Polychronis Lembesis (1848–1913), Greek painter Polychronis Tzortzakis (born 1989), Greek cyclist Polychronis Vezyridis (born 1974), Greek footballer Polychronis Tsigkas (born 2000), Greek/Cypriot basketball player