Vetrano is a southern Italian surname from western Sicily, Campania and Apulia, either derived from the town of Castelvetrano, Sicily, or from nicknames related to Latin ( English veteran). Notable people with the surname include:

Candela Vetrano (born 1991), Argentine actress Giulia Vetrano (born 2005), Italian swimmer Joe Vetrano (1918–1995), American football player Karina Vetrano (1986–2016), American speech-language pathologist and murder victim Stefano Vetrano (1923–2018), Italian politician

See also Vitrano

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