Santa Sofia may refer to:
Places Santa Sofia d'Epiro, an Arberesh town and comune in Cosenza, Italy Santa Sofia, Emilia–Romagna, a comune in the Province of Forlì-Cesena in Emilia–Romagna, Italy Santa Sofía, Boyacá, a town and municipality in Boyacá, Colombia
Churches and other buildings Santa Sofia, Benevento (8th century), a church in Benevento Santa Sofia, Naples (1487), a church in Naples Santa Sofia, Padua (10th century), a church in Padua Santa Sofia a Via Boccea (1968), a church in Rome Santa Sofia, Venice (11th century), a church in Venice Palazzo Santa Sofia, a palace in Mdina, Malta
Other uses Santa Sofia, an alternative name for the Italian wine grape Fiano
See also Hagia Sophia (disambiguation) Santa Sophia Sofia (disambiguation)