Kirtley is a surname. Notable people with the surname include:
Bill Kirtley, English football goalkeeper David Barr Kirtley (born 1977), American writer James Kirtley (born 1975), English cricketer John R. Kirtley (born 1949), American physicist Matthew Kirtley (1813–1873), English engineer Pat Kirtley, American guitarist and composer Pete Kirtley (born 1972), English songwriter, record producer and music entrepreneur Thomas Kirtley (1811–1847), English railway engineer Virginia Kirtley (1888–1956), American actress and writer William Kirtley (railway engineer) (1840–1919), English railway engineer William W. Kirtley (1897–1944), known as Bill, American anti-death penalty activist