John Sykes (1959–2025) was an English rock guitarist, vocalist and songwriter.
John Sykes may also refer to:
John Sykes (composer) (1909–1962), composer and music teacher John Sykes (politician) (born 1956), British Conservative Member of Parliament for Scarborough, 1992–1997 John H. Sykes, American businessman in Tampa Bay John Sykes (American businessman) (born 1955), co-founder of MTV, president of Entertainment Enterprises for Clear Channel Media Holdings John Sykes (footballer) (born 1950), English footballer John Sykes (American football) (born 1949), American football running back