McSpadden is a surname. Notable people with the surname include:
Clem McSpadden (1925–2008), American politician Dwight McSpadden (1932–1990), American football coach Gary McSpadden (1943–2020), American pastor, singer, songwriter, producer, television host and motivational speaker Lara McSpadden (born 1999), Australian women's basketball player Lealand McSpadden (born 1946), American racing driver Phil McSpadden, American softball coach Richard McSpadden (died 2023), American pilot and educator
See also Alex McSpadyen (1914–1978), Scottish footballer McSpadden Hollow, a valley in the U.S. state of Missouri