McNicholas is a surname. Notable people with the surname include:
Conor McNicholas, British journalist and magazine editor Derek McNicholas (born 1985), Irish hurler John T. McNicholas (1877–1950), Irish-born, American Roman Catholic bishop Joseph Alphonse McNicholas (1923–1983), American Roman Catholic bishop Lily McNicholas (1909 – 1998), Irish nurse in the Second World War Maura McNicholas, Irish camogie player Patrick McNicholas (1919–1990), Irish-born Canadian politician Paul McNicholas (rugby league) (born 1975), Australian rugby league player Steve McNicholas (born 1955), English actor and director
See also Archbishop McNicholas High School, a high school in Ohio, United States