Neamine (neomycin A) is a degradation product of the aminoglycoside antibiotic neomycin. Several derivatives of neamine are active against susceptible and resistant Gram-positive and Gram-negative bacteria.
Biosynthesis Neamine is a biosynthetic intermediate in the pathway which bacteria such as Streptomyces kanamyceticus use to make aminoglycoside antibiotics including lividomycin, neomycin and kanamycin. The immediate precursor is the aldehyde, 6'-oxoparomamine, which is acted on by the enzyme neamine transaminase:
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