Mackle ( or Ó Maicill) is a Scottish surname. It comes from the Middle Scots "Meikill" (also spelled "Meikle" or "Mekill"), meaning "big, large". Notable people with the surname include:
Barbara Jane Mackle (born 1948), American heiress and kidnapping victim Damian Mackle (born 1985), Northern Irish professional wrestler Mackle Brothers, American land developers Marisa Mackle (born c. 1973), Irish novelist
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