Zachos is both a surname and a given name. Notable people with the name include:
Surname Aristotelis Zachos (1871–1939), Greek architect Cosmas Zachos (born 1951), American physicist Helena Zachos (1856–1951), American educator and elocutionist, daughter of John James Zachos, American oceanographer and paleoclimatologist John Celivergos Zachos (1820–1898), Greek-American educator and elocutionist, father of Helen Stathis Zachos (born 1947), Greek computer scientist Vanessa Zachos, British actor
Given name Zachos Milios (1805–1860), Greek revolutionary