Mchedlidze is a Georgian surname. Notable people with the surname include:
Simon Mchedlidze (1856–1924), Georgian Orthodox martyr Guram Mchedlidze (1931–2009), Georgian biologist Levan Mchedlidze (born 1990), Georgian footballer Nana Mchedlidze (1926-2016), Georgian film director, actress and screenwriter Tamaz Mchedlidze (born 1993), Georgian rugby union player
See also