Three ships of the United States Navy have borne the name USS Paul Hamilton, named in honor of Paul Hamilton, (1762–1819), a veteran of the American War of Independence and the third Secretary of the Navy.

The first, , was a , launched in 1919 and scrapped in 1931. The second, , was a destroyer, launched in 1943 and struck in 1968. The third, , is an destroyer, launched in 1993.

See also , a Liberty ship , ships of a similar name