McCollough is a surname. Notable people with the surname include:
Aaron McCollough (born 1971), American poet Celeste McCollough (1926–2023), American scientist Clair McCollough (1904–1995), American broadcasting executive Evan McCollough (born 1987), American football player Jack McCollough (born 1978), fashion designer Jaylen McCollough (born 2000), American football player W. Alan McCollough (born 1950), American businessman
See also McCullagh MacCulloch McCulloch McCullough McCollough effect, an optical illusion, named after Celeste McCollough