McCance is a surname. Notable people with the surname include:
Chester McCance (1911–1956), Canadian football player Keith McCance (1929–2008), Australian politician John McCance (1775-1832), Irish politician Robert McCance (1898–1993), British academic Sean E. McCance, American orthopedic surgeon William McCance (1894–1970), Scottish artist
See also Elinore McCance-Katz, American physician, academic and government official McCance Glacier, a glacier of Antarctica