De Nooijer is a Dutch surname. Notable people with the surname include:
Bradley de Nooijer (born 1997), Dutch footballer Dennis de Nooijer (born 1969), Dutch footballer Gérard de Nooijer (born 1969), Dutch footballer Jeremy de Nooijer (born 1992), Dutch-born Curaçaoan footballer Teun de Nooijer (born 1976), Dutch field hockey player