McAnespie is a surname. Notable people with the surname include:
Aidan McAnespie (1965–1988), Irish Catholic killed during The Troubles Alex McAnespie, Scottish football player and manager Brenda McAnespie (born 1966), Irish ladies' Gaelic football player Kieran McAnespie (born 1979), Scottish footballer Ryan McAnespie, Irish Gaelic football player Steve McAnespie (born 1972), Scottish footballer