William Mathews may refer to:
William Mathews (cricketer) (1793–1858), English cricketer William A. Mathews (1800–1856), Texas colonist, soldier, courier and quartermaster in the Texas Revolution William Mathews (mountaineer) (1828–1901), English mountaineer and botanist William Gordon Mathews (1877–1923), federal judge and lawyer in West Virginia William Shirley Mathews (1848–1915, Osage Nation politician Bill Mathews (William Henry Mathews, 1919–2003), Canadian geologist
See also William Matthews (disambiguation)