Lettieri is an Italian surname. Notable people with the surname include:
Al Lettieri (1928–1975), American actor Dave Lettieri (born 1964), American cyclist Enzo Lettieri (born 1998), Argentine footballer Gabriel Lettieri (born 1975), Argentine footballer Gino Lettieri (born 1966), Italian football manager Mark Lettieri (born c. 1984), American guitarist Paola Lettieri, British-Italian chemical engineer Tino Lettieri (born 1957), Canadian international footballer Vinni Lettieri (born 1995), American ice hockey player