Society for the Prevention of Cruelty to Animals (SPCA) is a common name for non-profit animal welfare organizations around the world.
SPCA may also refer to:
Coagulation factor VII, sometimes called serum prothrombin conversion accelerator Secretory Pathway Ca²⁺ ATPase, a protein also known as SPCA Société Provençale de Constructions Aéronautiques, a French aircraft manufacturer that merged into SNCASE Sparse PCA (Sparse Principal Components Analysis), a specialised technique used in data analysis