Omodiagbe is a Nigerian surname. It is a male name and of Esan origin, which means "A child straightens the clan, or a child is the backbone of a clan". Omodiagbe is a combination of three different words in the Esan dialect (language). The three words are:

“ Omo” - meaning “child” “ dia” - meaning “to straighten” “ Ogbe” - meaning “clan” or “family”

The name Omodiagbe reflects the importance of children in societies and families.

Notable individuals with the name Darlington Omodiagbe (born 1978), Nigerian footballer Emmanuel Omodiagbe (born 1985), Nigerian footballer