Gus is a masculine given name.
Gus or GUS may also refer to:
Animals Gus (bear) (1985–2013), a polar bear at the Central Park Zoo in New York City Gus (fish) (died 2023?), a blue groper who swam alongside divers and snorkelers in the Sydney suburb of Cronulla in New South Wales, Australia
Arts and entertainment Gus (1976 film), an American comedy Gus (2011 film), an Australian animated short Gulder Ultimate Search, a Nigerian reality show Guster, formerly Gus, an American alternative rock band
Businesses GUS (retailer), a defunct British retailer Global University Systems, a Dutch education company Gus' Pretzels, a pretzel maker in St Louis, Missouri Gus's, a cafe in Canberra, Australia
Military and police Groupes urbains de sécurité, a defunct Moroccan police unit Gus-class LCAC, a Soviet Navy assault hovercraft class GUS, designation of slow westbound UG convoys in World War II
Places Gus, Kentucky, an unincorporated community Gus (river), Russia
Other uses Central Statistical Office (Poland) () Gravis Ultrasound, a PC sound card GUS reporter system, a molecular biology technique