Van Schuppen is a Dutch and Flemish surname. Notable people with the surname include:
Anne van Schuppen (born 1960), Dutch former long-distance runner Boris van Schuppen (born 2001), Dutch footballer Jacob van Schuppen (1670–1751), Baroque painter Jan H. van Schuppen (born 1947), Dutch mathematician and an academic researcher Pieter van Schuppen (1627–1702), Flemish painter and engraver and father of Jacob van Schuppen