Isnotú () is a tiny town located in Trujillo, Venezuela, roughly west of Caracas. It has an average daytime temperature of .Average emperatures World Weather Online. Retrieved on November 22, 2015.

Isnotú was founded by Bishop Mariano Martí on April 13, 1777.Hernández Caballero, Serafín. (1998). Gran Enciclopedia de Venezuela. Editorial Globe, C.A. Caracas. . Its name came from the Indigenous tribe that inhabited the area at the time of its founding, the Isnotúes.Vila, Marco Aurelio. Antecedentes coloniales de centros poblados de Venezuela, p 172. Caracas: Universidad Central de Venezuela, 1978.Universidad Central de Venezuela – Biblioteca Willy Ossott . UCV.ve. Retrieved on November 22, 2015.

Isnotú is the birthplace of Doctor José Gregorio Hernández. Daily, thousands of people come there to visit the Santuario (the Sanctuary) which was built as a sign of gratitude for miraculous healings attributed to Dr. Hernández.José Gregorio Hernández Biography . Tiwi.com. Retrieved on November 22, 2015.

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