My Sister's Keeper may refer to:

Novels My Sister's Keeper, 1961 novel by Ronald Verlin Cassill My Sisters' Keeper, 1970 novel by L. P. Hartley My Sister's Keeper, 1979 novel by Rachel Lindsay (Roberta Leigh), also named Janey Scott My Sister's Keeper (novel), 2004 novel by Jodi Picoult My Sister's Keeper, 2005 novel of the Journey of the Sacred King series by Janrae Frank

Films My Sister's Keeper (TV film), 2002 television movie, directed by Ron Lagomarsino My Sister's Keeper (film), 2009 film adaptation of the Jodi Picoult novel

Episodes "My Sister's Keeper", 1963 episode of (Gunsmoke) "My Sister's Keeper" (That Girl), 1969 "My Sister's Keeper" (Three's Company), 1978 "My Sister's Keeper" (Blossom), 1991 "My Sister's Keeper" (Digimon Adventure), 2000 "My Sister's Keeper" (The Listener), 2009 "My Sister's Keeper" (The Suite Life on Deck), 2010 "My Sister's Keeper", 2010 episode of Love That Girl!

Other uses My Sister's Keeper, non-governmental organization; see Eleanor Roosevelt Award for Human Rights

See also My Brother's Keeper (disambiguation) "Not My Sister's Keeper", episode of Zeke and Luther