Macedonia, under the name of Former Yugoslav Republic of Macedonia, competed at the 2012 Summer Olympics in London, United Kingdom, held from 27 July to 12 August 2012. This was the nation's fifth consecutive appearance at the Summer Olympics in the post-Yugoslav era.

Four athletes were selected to the team by wild card places, without having qualified, competing only in athletics and swimming. This was also the nation's smallest delegation to be sent to the Games in the post-Yugoslav era. Marko Blaževski, a medley swimmer and finance student at Wingate University in North Carolina, was appointed by the Macedonian Olympic Committee to be the nation's flag bearer at the opening ceremony. For the first time in Olympic history, Macedonia did not qualify athletes in freestyle wrestling, slalom canoeing, and shooting.

Macedonia failed for the third consecutive time to win an Olympic medal.

Athletics

Macedonian athletes received wild cards for both men's and women's 400 metres.

Key Note – Ranks given for track events are within the athlete's heat only Q = Qualified for the next round q = Qualified for the next round as a fastest loser or, in field events, by position without achieving the qualifying target NR = National record N/A = Round not applicable for the event Bye = Athlete not required to compete in round

Men AthleteEventHeat SemifinalFinalResultRankResultRankResultRankKristijan Efremov400 m47.927did not advance

Women AthleteEventHeat SemifinalFinalResultRankResultRankResultRankHristina Risteska400 m1:00.867did not advance

Swimming

Macedonia has selected one swimmer to qualify in the Olympic Games.Wingate University swimmer to compete in Olympics

Men AthleteEventHeatFinalTimeRankTimeRankMarko Blaževski400 m individual medley4:32.3834did not advance

Women AthleteEventHeatFinalTimeRankTimeRankSimona Marinova800 m freestyle9:28.4135did not advance

References