Dachshund homolog 2 is a protein that in humans is encoded by the DACH2 gene.Multiple transcript variants encoding different isoforms have been found for this gene.
Function This gene is one of two genes which encode a protein similar to the Drosophila protein dachshund, a transcription factor involved in cell fate determination in the eye, limb and genital disc of the fly. The encoded protein contains two characteristic dachshund domains: an N-terminal domain responsible for DNA binding and a C-terminal domain responsible for protein-protein interactions. This gene is located on the X chromosome and is subject to inactivation by DNA methylation. The encoded protein may be involved in the regulation of organogenesis and myogenesis, and may play a role in premature ovarian failure.
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