Andreas Seppi defeated Benoît Paire in the final, 6–3, 6–2 to win the singles tennis title at the 2012 Serbia Open.

Novak Djokovic was the reigning champion, but decided not to participate.

Seeds The top four seeds receive a bye into the second round.

Draw

Finals

Top half

Bottom half

Qualifying

Seeds

Qualifiers

Draw

First qualifier

Second qualifier

Third qualifier

Fourth qualifier

References Main Draw Qualifying Draw