Eizaguirre is a surname of Basque origins. Notable people with the surname include:
Agustín Eizaguirre (1897–1961), Spanish footballer Guillermo Eizaguirre (1909–1986), Spanish football goalkeeper and manager Ignacio Eizaguirre (1920–2013), Spanish football goalkeeper Jose Echegaray y Eizaguirre (1832–1916), Spanish civil engineer, mathematician, statesman, and dramatist Unai Osa Eizaguirre (born 1975), Spanish former road bicycle racer
See also Aguirre (disambiguation) Eyzaguirre (disambiguation) Izaguirre