Megalonema is a genus of long-whiskered catfishes native to South America.

Species There are currently seven recognized species in this genus: Megalonema amaxanthum Lundberg & Dahdul, 2008 Megalonema orixanthum Lundberg & Dahdul, 2008 Megalonema pauciradiatum C. H. Eigenmann, 1919 Megalonema platanum (Günther, 1880) Megalonema platycephalum C. H. Eigenmann, 1912 Megalonema psammium Schultz, 1944 Megalonema xanthum C. H. Eigenmann, 1912

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