James Wilkins may refer to:
James C. Wilkins (1787–1849), American businessman and Mississippi territorial legislator James N. Kienitz Wilkins, American filmmaker, artist, and writer James R. Wilkins Jr. (born 1945), American entrepreneur, philanthropist, and community leader James R. Wilkins Sr. (1910–1996), his father, American retailer, developer, community leader, and philanthropist