LS6 or LS-6 may refer to:
Rolladen-Schneider LS6, glider (1983–2003) GM 2500 engine LS6, straight-4 engine (1978–1979) GM LS engine LS6, V8 engine (2000s) Chevrolet Big-Block engine LS-6 (454in3), V8 engine (1970s) LS-6, a series of Chinese satellite-guided glide bomb. The Headingley and Hyde Park postcode area of Leeds LS6 (novel), by Mario Crespo IM LS6, Chinese car model