Jayaratne or Jayarathna () is a Sinhalese surname. Notable people with the surname include:
Jayarathna Samudika Jayarathna, 42nd Auditor General of Sri Lanka since 2026 Sidney Jayarathna (born 1962), Sri Lankan politician, MP (2001–2004, 2015–2020) Y. N. Jayarathna, Sri Lankan naval officer and hydrographer
Jayaratne Ajit Jayaratne, Sri Lankan businessman Anuradha Jayaratne (born 1985), Sri Lankan politician D. M. Jayaratne (1931–2019), Sri Lankan politician, 14th prime minister of Sri Lanka Ishan Jayaratne (born 1989), Sri Lankan cricketer Jayantha de S. Jayaratne, Sri Lankan army officer Osmund Jayaratne (died 2006), Sri Lankan academic and politician Piyankara Jayaratne (born 1964), Sri Lankan politician T. M. Jayaratne (born 1944), Sri Lankan singer Tilak Jayaratne (1943–2012), Sri Lankan broadcaster
See also Jayarathna Herath (born 1955), Sri Lankan politician, MP (2000–2024)