Hertwig is a German surname. Notable people with the surname include:
Benjamin Hertwig, Canadian poet Craig Hertwig (1952–2012), American football player Michael Hertwig (born 1960), German football player and manager Oscar Hertwig (1849–1922), German zoologist Paula Hertwig (1889–1983), German biologist, politician Richard Hertwig (1850–1937), German zoologist
See also Hertwig's sheath, a proliferation of epithelial cells