A phosphoprotein is a protein that is posttranslationally modified by the attachment of either a single phosphate group, or a complex molecule such as 5'-phospho-DNA, through a phosphate group. The target amino acid is most often serine, threonine, or tyrosine residues (mostly in eukaryotes), or aspartic acid or histidine residues (mostly in prokaryotes).Keyword - Phosphoprotein
Biological function The phosphorylation of proteins is a major regulatory mechanism in cells.
Clinical significance Phosphoproteins have been proposed as biomarkers for breast cancer.Liquid Biopsy Could Get Boost from Phosphoproteins. 2017Phosphoproteins in extracellular vesicles as candidate markers for breast cancer
See also Protein phosphorylation Phosphoserine
References