Bignami () is an Italian surname. Notable people with the surname include:
Adolfo Bignami (1845–1906), Italian painter and engraver Amico Bignami (1862–1929), Italian physician and pathologist Enrico Bignami (1844–1921), Italian merchant, jounralist and politician Galeazzo Bignami (born 1975), Italian politician Giovanni Bignami (1944–2017), Italian astrophysicist Osvaldo Bignami (1856–1936), Italian painter Otello Bignami (1914–1989), Italian violin maker Pietro Bignami (died 1830), Italian painter Vespasiano Bignami (1841–1929), Italian painter, cartoonist and writer
See also Bignami (Milan Metro), a metro station in Milan, Italy Marchiafava–Bignami disease, a neurological disease