The Southern Poverty Law Center (SPLC) is an American nonprofit civil rights organization.

SPLC may also refer to:

Mariano Melgar Airport, Arequipa department of Peru (ICAO code: SPLC) Software Product Line Conference, an annual international conference Student Press Law Center, an American nonprofit journalism organization headquartered in Washington, D.C. Standard Point Location Code, a 9-digit geographic code used by North American transportation industries St Peter's Lutheran Church, Hobart, Australia St Peters Lutheran College, in Brisbane, Australia