The following is a list of characters that first appeared in the New Zealand soap opera Shortland Street in 2010, by order of first appearance.

Loren Fitzpatrick

Loren Fitzpatrick was the vegetarian love interest for Daniel Potts (Ido Drent). After meeting at the cafe where Loren worked, the two started to date and Loren pressured Daniel to take up activism much to the annoyance of Daniel's mother Sarah (Amanda Billing). Loren turned out to be from a troubled home where she spent much of her time caring for her autistic brother. Daniel pressured Loren into sex and she seemed reluctant and blamed much of her social angst on her father Reuben Fitzpatrick (David Aston). The two did eventually become sexually active and Loren fell pregnant after a condom mishap. Though at first wanting to keep the baby, Loren was talked around by Sarah and ended up having an abortion before she fled the country.

Heather Sloane

Heather Sloane was the ex-girlfriend of Ben Goodall (Shaun Edwards-Brown). Heather was a patient and significantly older than Ben, thus bring great shock to Ben's ex lover – Tania Jeffries (Faye Smythe) when Heather confessed she and Ben had dated for 5 years and she had, in fact, paid his paramedic fees. Tania suspected Ben of being a gold digger and may have been after her mother, Yvonne's (Alison Quigan) money. Heather had cancer and though reassured of her safety by Ben, died on the operating table in February.

Brodie Kemp

Brodie Kemp was the immature med school friend of Hunter McKay (Lee Donoghue). Brodie arrived in March and proved poor for Hunter's relationship with Tracey (Sarah Thomson) when he burnt his arm seriously and asked her to steal equipment to heal it. He returned several months later, dropped out of med school and started to flat with Hunter and new girl - Penny Rourke (Carolyn Dando). Brodie was attracted to Penny and became bitter when she started to date Hunter. He fell in love with Sophie (Kimberley Crossman) but settled for Bella Cooper (Amelia Reid), who he soon fell in love with as well. He bought The IV with Bella's father, Murray (Matthew Chamberlain). However, with little money he was forced to take out a loan from some loan sharks. In 2011 Brodie's financial secrets ruined his relationship with Bella when she suspected he was cheating. However they soon reconciled and Murray bought Brodie out of the bar. Brodie soon started doing jobs for the terminally ill - Regan Ames (George Mason). When Brodie began to question Regan's illness, Regan set him up with class A drugs and Brodie was forced to flee New Zealand to escape some drug lords.

Isaac Worthington

Dr. Isaac John William Worthington was the playboy cousin of Chris Warner (Michael Galvin). Quickly after getting a job at the clinic, Isaac's intentions were clear when he attempted to romance both Libby Jeffries (Fleur Saville) and Tracey Morrison (Sarah Thomson). He briefly dated Tania (Faye Smythe) and Harry's (Reid Walker) primary school teacher before he started an intense feud with Luke Durville (Gerald Urquhart). He reconciled with Tania but cheated on her with Zoe (Gina Varela). He started to date Brooke Freeman (Beth Allen) but his overspending resulted in a lock on his trustfund and Isaac was forced to participate in an illegal operation to fund his yacht. The gang members involved ended up kidnapping Luke and when he was discovered alive in 2011, Isaac was forced to frame him for drug addiction so that he would not discover the truth. Bella Cooper (Ameila Reid) started to piece together the puzzle and Isaac got engaged to her to put her off the scent. They broke up however and Isaac finally got hold of his money but Luke returned knowing the truth and after attempting to murder his uncle, Isaac ended up fleeing the country without Brooke as he hoped. He was last seen in March stranded in the Philippines after his trust fund was again locked.

Astrid Chapel

Astrid Chapel was the drug addict who stabbed Hunter McKay (Lee Donoghue) in the arm with a needle during a botched burglary of an ambulance. Astrid and her junkie friend attempted to rob an ambulance whilst paramedic - Hunter was in it. Astrid ended up stabbing Hunter when he refused to hand over morphine. This left Hunter with an HIV scare and whilst Hunter waited for the results, his sister Sophie (Kimberley Crossman), organised an interview with Astrid. Astrid expressed guilt over the incident but was verbally abused by both Hunter and Callum McKay (Peter Mochrie) who arrived to save Sophie. Astrid was later in the same rehab group as Hunter when he fell victim to drug addiction and showed hatred at Hunter's "rich boy" ways as she was born a drug addict. She set him up with false drugs and got him expelled from the clinic.

Frankie Hull

Frankie Hull was the flamboyant party girl that worked at the bureau. Frankie first appeared when she showed attraction towards Isaac Worthington (Matt Minto), annoying Tracey (Sarah Thomson). She later went out drinking with Scotty (Kiel McNaughton) and returned home with him only to be kicked out by Tracey. She returned the next month and began a casual friendship with Hunter McKay (Lee Donoghue). The two agreed to go on a date but when Hunter saw her being judgmental towards a man who had attempted suicide, he broke it off, frustrated that she would likely judge his possible HIV status. Frankie hoped for a reconciliation but was declined.

Reuben Fitzpatrick

Dr. Reuben Fitzpatrick was the eccentric father of Loren (Sophia Johnson) and director of the acting group, the Ferndale Players. Amateur actors, Yvonne Jeffries (Alison Quigan), Ben Goodall (Shaun Edwards-Brown), Gerald Tippett (Harry McNaughton) and Daniel Potts (Ido Drent), all joined the club and were taken aback by Reuben's dominating personality. It was soon revealed he was suffering from a brain tumour and he apologized for his behaviour. He returned months later as a doctor at Sarah's (Amanda Billing) GP clinic. He was pleased his daughter was pregnant and encouraged Daniel to fight for his child. However, when Reuben learned Sarah had encouraged Loren to get an abortion, he cut ties with her and attempted to sabotage her business before he quit to avoid legal action.

Jewel Fitzpatrick

Jewel Fitzpatrick was the much younger wife of Reuben Fitzpatrick (David Aston). She was introduced as a possible love interest for Ben Goodall (Shaun Edwards-Brown) and was portrayed by Edwards-Brown's real life wife, Vicki. Vicki was part of her husband Reuben's drama group and was one of the lead roles alongside Ben. Jewel and Reuben's relationship was on the rocks and Jewel began to flirt with Ben to make Reuben jealous, infuriating Ben's partner Yvonne (Alison Quigan). Following Reuben's diagnosis of a brain tumour, the two reconciled and Jewel performed in the play to a successful review.

Doug Morrison

Doug Morrison was the corrupt policeman brother of Tracey Morrison (Sarah Thomson). Doug reentered Tracey's life when he landed a case in Auckland and immediately clashed with Tracey's flatmate. Scotty (Kiel McNaughton). Doug soon started to date Tania Jeffries (Faye Smythe), but it was clear he was hiding something and Doug finally admitted to Tracey he had fallen in with gangs and was illegally sabotaging their crime scenes. An upset Tracey agreed not to let the secret out but once Doug had left town, the guilt got to her and she got her brother arrested.

Leslie Grant

Leslie Grant was an actor who participated in the play Yvonne Jeffries (Alison Quigan) was directing. He was portrayed by broadcaster Paul Holmes, in a cameo appearance for Easter 2010. Leslie proved both arrogant and irritating, however turned out to be an amazing actor. Leslie's arrogance got the better of him however, when he knocked himself out mid show, accidentally locking himself in his dressing room.

Zoe Archer

Zoe Archer was the dietitian love interest for Chris Warner (Michael Galvin), who debuted in April 2010 as part of deaf awareness week. Zoe's son – Dallas (Zaire Armstrong) was deaf and Zoe came to a deaf awareness function to plee for Chris to operate on him. Chris did so and briefly became romantically involved with Zoe, however the surgery went wrong and Dallas got a severe reaction. Zoe broke it off with Chris and departed. She returned later in the year in a more central role. Zoe returned and reconciled with Chris, although she made it clear she was not interested in sex. Chris was devastated when he discovered Zoe had slept with his cousin Isaac (Matt Minto) in a sick attempt to seek revenge for the failed surgery on Dallas. Zoe was last seen belittling Isaac and making it obvious she had used him.

Hugh Sundae of The New Zealand Herald, criticized Varela's acting, calling it "awkward".

Leanne Miller

Leanne Miller first appeared in April 2010 and was portrayed by Jennifer Ludlam. She reprised the role in 2011 and again in 2014. She departed in September 2016. She later returned after her husband Howard Black died. She has recently reconciled with Damo Johnston after a near death experience caused by Erin Landry.

Eric Miller

Eric Miller was the schizophrenic brother of Nicole (Sally Martin). Nicole was initially hesitant to leave Tauranga with girlfriend – Maia Jeffries (Anna Jullienne) as she felt the need to nurse Eric, however Eric revealed he was back on his medication and under good eyes, allowing Nicole to finally let go. In 2012 Eric had a severe episode and Nicole was forced to return to Tauranga to nurse him. Nicole and Vinnie (Pua Magasiva) visited Eric in 2014 when Leanne complained of his laziness. A week later, Eric and Leanne moved to Auckland and Nicole successfully moved Eric into care away from his overbearing mother. Several years later Leanne visited Eric and met his two children. In 2017 Eric was arrested for drug smuggling in Thailand and Leanne visited him to help financially.

Henry Mapasua

Henry Mapasua was the childhood friend of Maxwell Avia (Robbie Magasiva). Henry reentered Maxwell's life in 2010 and got on well with his girlfriend Sarah (Amanda Billing). The two went into partnership with Henry's dentistry opening in Sarah's GP clinic. Henry encouraged Kieran Mitchell (Adam Rickitt) and Isaac Worthington (Matt Minto) to invest in his favourite horse but it soon became clear Henry was a conman and was using their money to his benefit. Kieran and Jane (Sia Trokenheim) successfully conned Henry out of thousands of dollars and Maxwell ended up calling the police on him. An upset Henry blamed the con on stress from the 2009 Samoa earthquake and tsunami and was arrested when he attempted to flee the country.

Jane Perry

Jane Perry was the barmaid who anonymously blackmailed Kieran Mitchell (Adam Rickitt) about the hit and run death of Morgan Braithwaite (Bonnie Soper). Kieran hired Jane to be a barmaid at the bar and began to get mysterious blackmail letters. It was soon clear to the audience that Jane was the culprit and Kieran tricked her into confessing which resulted in him taking her hostage. Jane admitted to formerly being a prostitute and having slept with Kieran's brother - Sean (Thijs Morris), who had confessed the crime. The two's rivalry resulted in an affair and they ended up conning Henry (Victor Rodger) out of several thousand dollars. Kieran paid Jane to leave but she returned several weeks later and attempted to blackmail him into leaving with her. She assaulted Kieran which ended in serious brain injury. Jane eventually ended up fleeing after the tables turned and Kieran blackmailed her on assault charges.

Ashton Fuller