Life Itself may refer to:
Films Life Itself (2014 film), a documentary, film adaptation of film critic Roger Ebert's memoir Life Itself (2018 film), an English-language romance drama film
Songs "Life Itself" (George Harrison song), a song by George Harrison from Somewhere in England "Life Itself", a song by Glass Animals from How to Be a Human Being "Life Itself", a song by Bruce Springsteen from Working on a Dream
Books Life Itself: A Memoir, a 2011 memoir by film critic Roger Ebert Life Itself: Its Origin and Nature, a 1981 book by Francis Crick Life Itself: A Comprehensive Inquiry Into the Nature, Origin, and Fabrication of Life, a 1991 book by Robert Rosen
Other Life Itself with Sanjay Gupta and Marc Hodosh, a health conference "Life, Itself", a Star Trek: Discovery season 5 episode