Frugoni is a surname originating in Italy. Notable people with the surname include:
Arsenio Frugoni (1914–1970), Italian historian Carlo Innocenzo Frugoni (1692–1768), Italian poet and librettist Chiara Frugoni (1940–2022), Italian historian Gian Bernardo Frugoni (1591–1661), Genoese doge Emilio Frugoni (1880–1969), Uruguayan politician Pietro Frugoni (1851–1940), Italian general Ramiro Martínez (rugby union) (born 1970), Argentine-born rugby union player, also known as Ramiro Martinez-Frugoni