Threlkeld is a surname. Notable people with the surname include:
Caleb Threlkeld (1676–1728), Irish botanist Dale Threlkeld, American artist Eleanor Threlkeld (born 1998), English cricketer Lancelot Threlkeld (1788–1859), English missionary, primarily in Australia Oscar Threlkeld (born 1994), English footballer Richard Threlkeld (1937–2012), American television news correspondent