Villiers-le-Sec may refer to the following communes in France:

Villiers-le-Sec, Calvados, in the Calvados département Villiers-le-Sec, Haute-Marne, in the Haute-Marne département Villiers-le-Sec, Nièvre, in the Nièvre département Villiers-le-Sec, Val-d'Oise, in the Val-d'Oise département