William Spence (1846–1926) was an Australian trade union leader and politician.
William Spence may also refer to:
William Spence (burgess), Virginia colonist and member of House of Burgesses
William Spence (entomologist) (c. 1783–1860), British economist and entomologist William Spence (mathematician) (1777–1815), Scottish mathematician William Spence (sculptor) (1793–1849), English sculptor based in Liverpool William Spence (MP), MP for Sussex William Spence (architect) (1806–1883), Scottish architect William Blundell Spence (1814–1900), English artist and art dealer William Robert Spence (1875–1954), Scottish trade union leader William Wallace Spence (1815–1915), Baltimore financier William Spence (schoolmaster), 17th-century Scottish schoolmaster imprisoned for teaching Presbyterianism William Spence (footballer), English footballer
See also Bill Spence (disambiguation)