Thomas Smythe (c. 1558 – 1625) was an English merchant and politician.
Thomas Smythe may also refer to: Thomas Smythe (customer) (1522–1591), the former's father, and English collector of customs duties Sir Thomas Smyth, 2nd Baronet (died 1732), British Army officer and politician Thomas Smythe, 1st Viscount Strangford (1599–1635), viscount in the Peerage of England Thomas Smythe (artist), (1825–1906) English artist based in Suffolk
See also Thomas Smith (disambiguation) Thomas Smyth (disambiguation)